Prednisolone acetate is a synthetic adrenocorticoid with the general properties of prednisolone. Adrenocorticoids diffuse across cell membranes to complex with cytoplasmic
Adult: PO Allergic and inflammatory disorders 5-60 mg/day, in 2-4 divided doses. Rheumatoid arthritis Initial: 5-7.5 mg/day, adjust dose if needed. Multiple sclerosis 200 mg/day for 1 wk, then 80 mg every other day for 1 mth. IV/IM Allergic and inflammatory disorders Given as Na phosphate ester: 5-60 mg prednisolone base/day. Ophth Conjunctivitis As 0.12 or 1% acetate susp: Instill 1-2 drops 2-4 times/day. Higher frequency may be used during the initial 24-48 hr. Re-evaluate if there is no improvement after 2 days of treatment. Otic Allergic and inflammatory conditions of the ear As 0.5 or 1% acetate or phosphate soln: Instill as directed. Intra-articular Joint inflammations As acetate: 5-25 mg. As phosphate: 2-30 mg. As terbutate:4-40 mg. Topical Rheumatoid arthritis As farnesylate: Apply to the affected area as necessary.
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Prednisolone acetate is a synthetic adrenocorticoid with the general properties of prednisolone. Adrenocorticoids diffuse across cell membranes to complex with cytoplasmic receptors and subsequently stimulate synthesis of enzymes with anti-inflammatory effects. Glucocorticoids inhibit the oedema, fibrin deposition, capillary dilation and phagocytic migration of the acute inflammatory response as well as capillary proliferation, deposition of collagen and scar formation.
Prednisolone acetate has, on a weight to weight basis, a potency three to five times that of hydrocortisone.
Patients with hypothyroidism, cirrhosis, ulcerative colitis, CHF, convulsive disorders, thrombophlebitis, peptic ulcer, elderly. DM, hypertension, psychological disturbances, osteoporosis; pregnancy, lactation. Adrenal suppression and infection. May cause irreversible growth retardation, glaucoma, corneal perforation. Topical: Broken or infected skin. Not to be applied over large areas under occlusive dressings.
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